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Glanders

Etiology Burkhoderia mallei (gm –ve)

Epidemiology

  • Glanders is mostly cronic in horse
  • Disease rum acute course in horse
  • Route of infection is injection mainly
  • It is grandually dinimished due to the use of mullein for diagnosis,strict isolation & adequate sanitation
  •  Cattle and pig are abeolutely resistant

Pathogenesis

Injection of contaminated food and water

enter lymphaties and penetrate

?

Penetrate pharyngeal &  intertional mucosa

?

General circulation

?

Pulmonary capillaries

?

Incite inflamn Rxn and serous

exudate from in perialvelor & perilronchial C.T.

(septicemia)

?

Panetrate fronchial wall & enter lumen (void in secretion)

?

Bronchopneunomia

?

Nodules formed in lung & skin

{Macrophage ? epitheloid cell ? giant cell}

{fibrinous granulation millary lesion}

?

Nodules may ulceratcl.

Symptoms

  • Nasal discharge (grey, catarrhal & oily)
  • Millet seed shape grayish nodule forms in upper resr tract
  • Oedematous submaxillary lymp nodues
  • Chromic cough, respr distress & intermittent fever
  • Qedema of hind limb down upto hock accompanied with discharge from lymph mode
  • Farcy
  • Formation of nodules & ulcer along lymphatic channel of skin

Lesions

Lungs –   milliary nodules

Punched out ulcer ( ulcer do not heal)

  • Nodules & ulcer in nasal septum

Farcy

  • Lymphangitis & lymphadenitis of hind limb
  • Small nodule ( farcy bud) fromed along the course of lymph vessels
  • Nodule may popen & discharge oily pus

Diagnosis

1. Mallein test

  • s/c or thermal test
  • ophthalmic test
  • intradermopalpelral test

2. C.F. T.

3. Indirect haemagglutination test

4. Strauss reaction

Intraperito inj of suspected matural in male guinea pig  à   painful orchitis+ve

Control

  • Carcass must be buried & incinerated
  • Premises should be vigorously disinfected
  • Isolation, testing & feed residue should be burnt and buried
  • Catarrhal Fpurulent, tenacious thick and ropy
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