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Epidemiology

Route of transmission

Direct contact, inhalation, conjunctiva acute course of disease with symptom of H.S.

Pathogenesis 

Virus reaches blood airculation

Through nasopharynx & tonsil  

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Multiply rapidly in blood

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Invade vascular endothelium

& cause degenration

?

obliteration of their luman

as a resultof end arteritis

?

infarction & necrosis of spleen Kidney & intestine

Clinical finding

  • High rise of temp. & erythematous patches
  • Vomition, severe diarrhea (offensive)
  • Hyperemia of skin with purplish discolouration of snout, ear, abdomen & inner sides of legs
  • Peculiar blotching effect on ear (irregular spot)
  • Wobbing gait, ataxia, tremor, convulsion,
  • Still bird or abnormal piglet

Lesion

  • Petechial & ecchmotic haemorrhage in all serous surface (pleura, peritoneum)
  • Liver is dark, congested
  • Turkey egg appearance of kidney removel  of capsule show button ulcer

Diagnosis

  • Pathognomic PM lesion
  • Histopathological examination
  • Animal inoculation test
  • Gel diffusion precipitation test
  • C.F.T, HA, N.T., FAT

Control

  1. Slaughter of affected animals, they should be buried & premises is properly disinfected
  2. All pig in form should kept under strict vigillance
  3. Restriction of movement of pig
  4. Vaccine

Lesion

  •  Viral pncumonic lesion i.e. atelective or consolidated and dark red to purple red lung.
  • Bronchial & mediastinal lympnode are oedematious, pulmonary oedema
  • Generalized lymphadenopathy, hepatic congestion and pulmonary consolidation.

Diagnosis Tools

  1. Microbiological test / serological test
  2. Biochemical test (gm Vi C)
  3. Bio-technological test
  4. Biological test / cultural examination

Bio-Technological Test

  1. Determination of ucleic acid
  2. P.C.R.and real time PCR
  3. Restriction fragment length polymorphism (RFLP)
  4. D.N.A. prole and D.N.A.microarry technology
  5. Detection of protain
  6. Immunoblotting .PA GE
  7. ELISA
  8. Antibody detection
  9. Competitive ELISA, serological test
  10. Nanotechnology

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